Fast, ligand- and solvent-free copper-catalyzed click reactions in a ball mill

Thorwirth, Rico; Stolle, Achim; Ondruschka, Bernd; Wild, Andreas; Schubert, Ulrich S.

Abstract:

A new, ligand- and solvent-free method for the Huisgen 1,3-dipolar cycloaddition (click reaction) was developed using a planetary ball mill. Besides various alkynes and azides, a propargyl functionalized polymer was converted by mill clicking. Moreover, it was possible to carry out a click polymerization in a ball mill.

Year:

2011

Type of Publication:

Article

Journal:

Chemical Communications

Volume:

47

Pages:

4370 - 4372